Reduction of intraoperative blooding and avoidance of perioperative transfusion are contributing factors for not only reducing postoperative complication but also improving long-term outcomes after liver resection. Until now, there is no consensus about the best technique to minimize blood loss during liver resection. Radiofrequency-based bipolar sealing device (AquamantysTM) is a relatively new instrument designed for effective coagulation during liver resection. This device delivers radiofrequency energy coupled with saline solution irrigation for hemostatic sealing at lower temperatures (<100°C) than conventional electrocautery devices. This device functions to shrink the collagen in the walls of the tissue vessels without causing charring or burning, in contrast to standard electrocautery. A recent randomized controlled study by Kaibori demonstrated that Compared with standard bipolar cautery, the bipolar sealer showed lesser blood loss during transection and blood loss divided by resection area (P = .0079 and .0008, respectively), shorter transection time (P = .0025), faster speed of transection (P < .0001), and fewer ties and ties divided by resection area required during transection (P < .0001). In addition, the combined use of Ultrasonic dissector and AquamantysTM was found to be the preferred technique for both open and laparoscopic liver resection in the survey of an international panel of experts. In this lecture, I’d like introduce how AquamantysTM works in detail, review the literatures about the benefits during liver resection and share my experience on how it can be effectively applied for both open and laparoscopic liver resection.