Detailed Abstract
[Oral Presentation 5 - Biliary & Pancreas (Pancreas Disease/Surgery)]
[OP 5-6] Association of CTC and MTV in pancreatic cancer
Hyun Soo SHIN1 , Hyung Sun KIM1 , Jung Min LEE1 , Ju Yeon LEE1 , Jun Hyung KIM1 , Youn Soo SEO1 , Atish Darshan BAJRACHARYA1 , Ki-ho HAN1 , Joon Seong PARK*1
1 Department Of Surgery, Gangnam Severance Hospital, REPUBLIC OF KOREA
Background : Pancreatic cancer is a deadly disease, mainly because of early metastasis. Predicting prognosis of pancreatic cancer patients will increase the survival rate of cancer. Metabolic Tumor Volume (MTV) and Circulating Tumor Cells (CTC) are notable prognostic factors and biomarkers of tumors. But no study has been done about the association of CTC and MTV in pancreatic cancer.
Methods : This study enrolled patients with PDAC who were treated between July 2018 and December 2021 at Gangnam Severance Hospital. DIS-μChip was used to isolate CTCs from the blood of pancreatic cancer patients. The association between CTC and MTV was evaluated using the Mann Whitney U test and Pearson’s correlation analysis.
Results : Metabolic tumor volume (MTV) and CTC count are correlated in the study (P < 0.001). Median Recurrence Free Survival (RFS) was 6.1 months versus 8.4 months in patients with higher CTC counts (P<0.05). Radiomic features of PET CT (gray level non uniformity, entropy, coarseness, joint energy, maximum probability) were also identified to have a relationship with the CTC count. In the multivariate analysis, CTC independently predicted RFS after curative resection of pancreatic cancer. This study showed that CTC counts are higher in patients with larger metabolic tumor volume and heterogenous cancer. Both the CTC counts and tumor volume were strong predictors of RFS after curative resection.
Conclusions : These findings identify the relationship between MTV and CTC. Metabolic tumor volume measurements may provide complementary findings of CTC counts and tumor heterogenous informations. Used together or alternatively, they can be used to anticipate prognosis of pancreatic cancer.
Methods : This study enrolled patients with PDAC who were treated between July 2018 and December 2021 at Gangnam Severance Hospital. DIS-μChip was used to isolate CTCs from the blood of pancreatic cancer patients. The association between CTC and MTV was evaluated using the Mann Whitney U test and Pearson’s correlation analysis.
Results : Metabolic tumor volume (MTV) and CTC count are correlated in the study (P < 0.001). Median Recurrence Free Survival (RFS) was 6.1 months versus 8.4 months in patients with higher CTC counts (P<0.05). Radiomic features of PET CT (gray level non uniformity, entropy, coarseness, joint energy, maximum probability) were also identified to have a relationship with the CTC count. In the multivariate analysis, CTC independently predicted RFS after curative resection of pancreatic cancer. This study showed that CTC counts are higher in patients with larger metabolic tumor volume and heterogenous cancer. Both the CTC counts and tumor volume were strong predictors of RFS after curative resection.
Conclusions : These findings identify the relationship between MTV and CTC. Metabolic tumor volume measurements may provide complementary findings of CTC counts and tumor heterogenous informations. Used together or alternatively, they can be used to anticipate prognosis of pancreatic cancer.
SESSION
Oral Presentation 5
Room A 3/24/2023 3:50 PM - 4:40 PM