Detailed Abstract
[Oral Presentation 4 - Liver (Transplantation)]
[OP 4-7] Effect of weight reduction on liver volume in living liver donor with steatosis
Kwangpyo HONG2 , Kwang-Woong LEE*1 , YoungRok CHOI1 , Su Young HONG1 , Sola LEE1 , Hyun Hwa CHOI1 , Jiyoung KIM1 , Jae-Yoon KIM1 , Jaewon LEE1 , Jeong-Moo LEE1 , Suk Kyun HONG1 , Nam-Joon YI1 , Kyung-Suk SUH1
1 Department Of Surgery, Seoul National University College Of Medicine, Seoul, 03080, Korea, REPUBLIC OF KOREA
2 Department Of Surgery, Uijeongbu Eulji Medical Center, Eulji University School Of Medicine, Uijeongbu, Korea, REPUBLIC OF KOREA
Background : If potential live liver donors are accompanied by steatosis, the donation will proceed after weight reduction. Weight reduction can reduce liver volume, affecting the graft-to-recipient ratio. Therefore, this study aims to evaluate a decrease in liver volume after weight reduction and analyze the risk factors affecting liver volume reduction.
Methods : From January 2016 to December 2020, we conducted a retrospective medical chart review of 147 potential liver donors with steatosis who participated in a weight reduction program due to living donor liver transplantation at Seoul National University Hospital.
Results : Ninety-seven (66%) donors underwent donor hepatectomy after weight reduction. After weight reduction, liver volume showed a statistically significant decrease (from 1399.6 ± 315.4 to 1283.6 ± 171.2 ml, P < 0.05). The weight reduction in the large liver volume reduction (≥10%) was more significant than that in the group with small liver volume reduction (5.8 ± 5.2 vs. 9.4 ± 4.3 %, P < 0.05), and AST (from 23.5 ± 9.7 to 22.2 ± 18.5 vs. from 27.2 ± 15.8 to 17.7 ± 4.4 U/L, P < 0.05), ALT (from 23.5 ± 9.7 to 22.2 ± 18.5 vs. from 27.2 ± 15.8 to 17.7 ± 4.4 U/L, P < 0.05). As a result of analyzing the risk factors for large liver volume reduction, weight reduction (%), and an ALT abnormality were analyzed (odds ratio [OR] = 1.184; 95% CI 1.054-1.329, OR = 5.502; 95% CI 1.660-18.229; all P < 0.05). There were more cases in potential liver donors with risk factors in which large liver volume reduction after weight reduction and a considerable reduction in GRWR was reported.
Conclusions : Potential liver donors with 7% or more weight reduction or an ALT abnormality required re-measurement of liver volume after weight reduction for re-measurement of graft-to-recipient ratio.
Methods : From January 2016 to December 2020, we conducted a retrospective medical chart review of 147 potential liver donors with steatosis who participated in a weight reduction program due to living donor liver transplantation at Seoul National University Hospital.
Results : Ninety-seven (66%) donors underwent donor hepatectomy after weight reduction. After weight reduction, liver volume showed a statistically significant decrease (from 1399.6 ± 315.4 to 1283.6 ± 171.2 ml, P < 0.05). The weight reduction in the large liver volume reduction (≥10%) was more significant than that in the group with small liver volume reduction (5.8 ± 5.2 vs. 9.4 ± 4.3 %, P < 0.05), and AST (from 23.5 ± 9.7 to 22.2 ± 18.5 vs. from 27.2 ± 15.8 to 17.7 ± 4.4 U/L, P < 0.05), ALT (from 23.5 ± 9.7 to 22.2 ± 18.5 vs. from 27.2 ± 15.8 to 17.7 ± 4.4 U/L, P < 0.05). As a result of analyzing the risk factors for large liver volume reduction, weight reduction (%), and an ALT abnormality were analyzed (odds ratio [OR] = 1.184; 95% CI 1.054-1.329, OR = 5.502; 95% CI 1.660-18.229; all P < 0.05). There were more cases in potential liver donors with risk factors in which large liver volume reduction after weight reduction and a considerable reduction in GRWR was reported.
Conclusions : Potential liver donors with 7% or more weight reduction or an ALT abnormality required re-measurement of liver volume after weight reduction for re-measurement of graft-to-recipient ratio.
SESSION
Oral Presentation 4
Room C 3/24/2023 10:10 AM - 11:10 AM